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Email messages can be protected to help preserve content confidentiality. Microsoft 365 offers a service called Message Encryption which you can use to send protected messages. Messages sent via Message Encryption can only be read by the recipient and can be configured to disallow forwarding to other users.

This article covers how to send an encrypted message.
The preferred Microsoft Message Encryption functionality does not rely on local client certificates. If you attempt to send an email message, and see an Invalid Certificate error, it may be attempting to encrypt the message using local S/MIME settings and certificates.